Core Competencies

Process Research

  • Custom synthesis and synthetic route evaluation from g to kg for API’s or intermediates

Process Development

  • Custom synthesis from kg - metric tons
  • cGMP manufacturing of pharmaceutical actives and intermediates for clinical trials

Core Technologies:
 Core Chemical Families:
  • Chlorinations-
    POCl3, SOCl2, PCl3
  • Brominations
  • Vilsmeier-Haack Reaction
  • Grignard Reaction
  • Chlorosulfonation
  • Freidel-Crafts Reactions
  • Nitrations
  • Benzylic Amination
  • High Temperature Reactions
  • Chiral Synthesis
  • Polymerization
  • Alkylations
  • Reductions
    (NaBH4, LAH, Vitride)
  • Cyanoethylation
  • Esterification
  • Low pressure Hydrogenation
  • Imidazoles/Imidazolines
  • Aromatics
  • Pyrimidines
  • Pyridines
  • Purines
  • Tetralones
  • Alkylphosphonic Acids
  • Indoles
  • Oxazoles

NCEs: APIs and Advanced Intermediates

Targeted Approach:

  • Partner with multi-national and emerging/virtual pharma companies that manufacture and develop unique life science products
  • Offer higher value products, including those that are chemically complex and difficult-to-manufacture
  • Main target opportunities:
    - Aggressive development schedule
    - Production volumes range from tens of kilograms to low metric tons
    - Unique pre-formulation capability » “get it right the first time approach”, enabling drugs to reach the market faster and with greater cost savings